To summarize the nursing experience of a patient with huge space occupying of cardiac non-Hodgkin lymphoma. The key points of nursing include：monitoring and volume management of circulatory system,predictive nursing of percutaneous ventricular septal biopsy,nursing of individual chemotherapy complications,rehabilitation guidance during acute heart failure in bed,risk management of cross-hospital transport,and individual psychological nursing. After careful multidisciplinary treatment and nursing care,the patient was getting better;the heart tumor was smaller than before;the cardiac function increased from level Ⅳ to Ⅱ;no chest tightness,shortness of breath and discomfort were reported after walking on the ground for 30 min.